3DBS supplies and customizes scaffolds as per the demand of its customers. Using proprietary electrospinning technology, we use natural and/or synthetic polymers with different degradation rates, thickness and pore sizes to produce fibrous matrices.
With this technology, we generate membranes with high mechanical performance, hydrophilic or hydrophobic, serving various applications in the field of regenerative medicine and tissue engineering.
Dentistry, bone regeneration, in vitro 3D models, biodressings, nano and microfilters, etc.
The great differential of our scaffolds is the possibility of incorporating bioactive or bioinductive molecules, for example: the essential oils of copaiba and citronella.
In an innovative project funded by PIPE/FAPESP, 3DBS develops vascular grafts and vascularized tissues, one of the biggest challenges in the field of tissue engineering.
The association of electrospinning and bioprinting techniques has been shown to be promising for the development of new biomaterials and applications. 3DBS has hybrid systems that allow you to work with both technologies at the same time.
Cell proliferation on the electrospun scaffold.
Dye silver nanoparticles.
The first step is the preparation of a poly (lactic-co-glycolic acid) PLGA solution, a bioresorbable polymer, with copaiba oil-resin
The polymer solution is placed in a syringe and then electrospun. The result is a deposition of fibrous matrix (or scaffold), formed by aligned or random filaments. The Fibrilla Scaffolds™ is sterilized with gamma radiation (γ).
In an oven at 37 °C, cells of the patient responsible for the synthesis of collagen, called fibroblasts, are cultured on the Fibrilla Scaffold™. Cells grow, proliferate and differentiate
The pore size of the Fibrilla Scaffolds™ matrix allows the migration and proliferation of fibroblasts, bonding to each other and growing into layers forming a three-dimensional (3D) structure. This process takes 20 to 30 days
Finally, the artificial skin (or dermal substitute) formed by the Fibrilla Scaffold™ and dermal cells is ready to be implanted in patients with severe skin lesions, such as third degree burns, ulcers and bedsores
